Growth Factors

Czubayko Lab

phone: +49 (0)6421-28-65003 email: czubayko@staff@staff.uni-marburg.de

We are interested in pharmacological targeting of oncogenes and growth factors relevant for malignant disease using mouse and tissue culture model systems.

Team
  • Frank Czubayko
    phone +49 (0)6421 28-65003   email: Frank Czubayko
  • Maria Hauswald
    phone +49 (0)6421 28-65035   email: Maria Hauswald
  • Fatma Aktuna
Research
  • Development of novel gene targeting strategies based on RNAi/siRNAs, ribozymes
  • Polyethylenimine (PEI)-based nanoparticles for the therapeutic in vivo delivery of small RNA molecules
  • Functional analysis of various growth factors and receptors, relevant in tumor growth and tumor angiogenesis
    (e.g., HER-1/EGFR, HER-2/erbB2, FGF-BP, PTN, ALK, Pim-1)
  • Development of novel treatment strategies based on the specific knockdown of pathologically relevant genes
Selected Publications
  • A sensitive polymerase chain reaction-based method for detection and
    quantification of metastasis in human xenograft mouse models.
    Malek A, Catapano CV, Czubayko F, Aigner A.
    Clin Exp Metastasis. (2010) 27:261-71.
  • RNAi-mediated gene-targeting through systemic application of
    polyethylenimine (PEI)-complexed siRNA in vivo.
    Urban-Klein B, Werth S, Abuharbeid S, Czubayko F, Aigner A.
    Gene Ther. (2005) 12:461-6.
  • Ribozyme-targeting of a secreted FGF-binding protein (FGF-BP) inhibits proliferation
    of prostate cancer cells in vitro and in vivo.
    Aigner A, Renneberg H, Bojunga J, Apel J, Nelson PS, Czubayko F.
    Oncogene. (2002) 21:5733-42.
  • A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.
    Czubayko F, Liaudet-Coopman ED, Aigner A, Tuveson AT, Berchem GJ, Wellstein A.