How disease mechanisms, acting at the molecular level of single synapses, affect the activity within human synaptic networks is addressed by the help of multi electrode arrays. Our combinatorial approach will deliver a valuable tool to identify targets in a human background and to screen for molecules that act on human synaptic networks and potentially “cure” disease related synaptic deficits.
- human iPSC culture
- small molecule directed neural differentiation
- multi electrode arrays
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